کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1965794 1538681 2013 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Role of leptin and adiponectin in insulin resistance
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Role of leptin and adiponectin in insulin resistance
چکیده انگلیسی

Adipose tissue is a major source of energy for the human body. It is also a source of major adipocytokines adiponectin and leptin. Insulin resistance is a condition in which insulin action is impaired in adipose tissue and is more strongly linked to intra-abdominal fat than to fat in other depots. The expression of adiponectin decreases with increase in the adiposity. Adiponectin mediates insulin-sensitizing effect through binding to its receptors AdipoR1 and AdipoR2, leading to activation of adenosine monophosphate dependent kinase (AMPK), PPAR-α, and presumably other yet-unknown signalling pathways. Weight loss significantly elevates plasma adiponectin levels. Reduction of adiponectin has been associated with insulin resistance, dyslipidemia, and atherosclerosis in humans. The other major adipokine is leptin. Leptin levels increase in obesity and subcutaneous fat has been a major determinant of circulating leptin levels. The leptin signal is transmitted by the Janus kinase, signal transducer and activator of transcription ((JAK-STAT) pathway. The net action of leptin is to inhibit appetite, stimulate thermogenesis, enhance fatty acid oxidation, decrease glucose, and reduce body weight and fat.


► Major adipocytokines adiponectin and leptin
► Adiponectin decreases with increase in the adiposity.
► Reduction of adiponectin has been associated with insulin resistance, dyslipidemia, and atherosclerosis.
► Leptin levels increase in obesity.
► Leptin signal is transmitted by the Janus kinase, signal transducer and activator of transcription ((JAK-STAT) pathway.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinica Chimica Acta - Volume 417, 18 February 2013, Pages 80–84
نویسندگان
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