کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1965825 | 1538694 | 2012 | 4 صفحه PDF | دانلود رایگان |
BackgroundCopper and zinc are essential trace elements and nutrients, which have important roles in physiology and disease and as cofactors in many metabolic pathways. We established age- and gender-specific reference intervals for serum copper and zinc, with a large healthy pediatric population.MethodsA total of 2115 clinically healthy children, 85.4% Caucasian, were enrolled: 1098 boys and 1017 girls 0.5–18 y. Serum copper and zinc concentrations were measured by inductively coupled plasma-mass spectrometry (analytical measurement range: 10–400 μg/dl for each). Statistical analyses and related calculations were performed using the STATA Statistical software and R software.ResultsThere were no significant effects of gender or fasting status. For copper, but not zinc, there were significant differences in the reference intervals by age. Based on the central 95% and 95% confidence intervals, the resulting reference interval determined for serum zinc was 64–124 μg/dl. The age-dependent reference intervals for serum copper were 75–153 μg/dl for those < 10.3 y, 64–132 μg/dl for those 10.3–12.5 y and 57–129 μg/dl for those > 12.5 y.ConclusionsOur data defined reference intervals for serum copper and zinc in an American, clinically healthy, pediatric population.
► Pediatric reference intervals for serum copper and zinc were established with 2115 clinically healthy children.
► There were no significant effects of gender on serum copper and zinc.
► There were significant differences in the reference intervals by age, for copper, but not zinc.
Journal: Clinica Chimica Acta - Volume 413, Issues 5–6, 22 March 2012, Pages 612–615