کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1965855 1538713 2010 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
ACE inhibitor use was associated with lower serum dehydroepiandrosterone concentrations in older men
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
ACE inhibitor use was associated with lower serum dehydroepiandrosterone concentrations in older men
چکیده انگلیسی

ContextAngiotensin converting enzyme (ACE) activity may influence the production of adrenal androgen precursors and testosterone. Use of ACE inhibitors may therefore have an influence on serum sex hormone concentrations in older men.Design and Methods1486 out of 2,000 community-dwelling Chinese men aged 65 years who participated in a cohort study were randomly selected to have archived fasting morning serum analyzed for androgen precursors and sex hormones. DNA was extracted from whole blood and analyzed for ACE gene I/D polymorphism.ResultsSubjects with the ACE gene D allele (higher ACE activity) had higher serum dehydroepiandrosterone (DHEA) sulphate and DHEA than those with I/I genotype (P = 0.014 and 0.018 respectively, Mann Whitney test). These differences were not significant after Bonferroni correction. Among those with history of hypertension, but without diabetes mellitus or cardiac failure, users of ACE inhibitors had significantly lower serum DHEA (median 1.78 versus 1.49 ng/ml in non-users, P = 0.0074, Mann Whitney test) and also tended to have lower serum androstenedione and androst-5-ene-3β,17β-diol (0.68 versus 0.72 ng/ml in non-users; 552.4 versus 624.1 pg/ml respectively, both P values < 0.05). Serum testosterone and estradiol were not significantly changed.ConclusionsACE inhibitor use was associated with lower serum DHEA in older men.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinica Chimica Acta - Volume 411, Issues 15–16, 5 August 2010, Pages 1122–1125
نویسندگان
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