کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1966234 1538717 2010 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Association of estrogen receptor-α gene polymorphisms with cardiac autonomic nervous activity in healthy young Japanese males
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Association of estrogen receptor-α gene polymorphisms with cardiac autonomic nervous activity in healthy young Japanese males
چکیده انگلیسی

BackgroundEstrogens exert beneficial effects on the cardiovascular system that are mediated by estrogen receptors. We examined the association between the estrogen receptor α gene (ESR1) PvuII and XbaI polymorphisms and cardiac autonomic nervous function in Japanese males.MethodsWe examined 252 young healthy males for association of ESR1 PvuII and XbaI polymorphisms and short-term heart rate variability (HRV) during supine rest and in a standing position. The very low frequency (VLF), low frequency (LF), and high frequency (HF) components of HRV were quantified by frequency domain analysis.ResultsCarriers of the ESR1 PvuII C allele had higher mean blood pressure (BP), while the XbaI GG genotype was significantly associated with higher diastolic and mean BP, but lower HR. In the haplotype analysis, carriers of the ESR1 haplotype 2 (PvuII C and XbaI A) allele had a higher systolic and mean BP, and lower HRV spectral powers (total power, VLF, LF, and HF components) in a supine rest compared with those of non-carriers.ConclusionsThe ESR1 PvuII and XbaI haplotype is associated with BP variation and the reduction in cardiac autonomic nervous activity in young Japanese males, which may be precursors of future pathological episodes of cardiovascular diseases.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinica Chimica Acta - Volume 411, Issues 7–8, 2 April 2010, Pages 505–509
نویسندگان
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