کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1966390 1538720 2010 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Association of alpha 2A adrenergic receptor gene (ADRΑ2A) polymorphism with irritable bowel syndrome, microscopic and ulcerative colitis
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Association of alpha 2A adrenergic receptor gene (ADRΑ2A) polymorphism with irritable bowel syndrome, microscopic and ulcerative colitis
چکیده انگلیسی

BackgroundAlpha 2 adrenergic receptors (α2 ARs) play a central role in the regulation of systemic sympathetic activity. Prejunctional alpha 2A adrenoceptor regulates through negative feedback at presynaptic nerve ending. A-1291 C > G polymorphism located in α2-adrenergic receptor gene (ADRΑ2A) has been identified. We investigated the possible association between 1291 C > G polymorphism in the promoter region of ADRΑ2A in clinical subtypes of IBS, ulcerative and microscopic colitis patients.MethodsThis prospective case control study included 92 patients with diarrhea predominant IBS (D-IBS), 44 with constipation predominant IBS (C-IBS), 15 with alternating diarrhea and constipation IBS (M-IBS), 75 ulcerative colitis (UC), 41 microscopic colitis (MC) and 100 healthy controls. The subjects were genotyped by using PCR amplification of the promoter region of ADRΑ2A gene followed by digestion with the restriction enzyme MspI. The study was approved by the institute ethical committee.ResultsA strong genotypic association was observed between α2A-1291 C > G polymorphism and D-IBS (χ2 = 6.38, df = 2, p < 0.05). There was no significant difference in α2A-1291 C > G genotype and allele frequency between C-IBS, M-IBS, UC, MC cases and control subjects.ConclusionsA significant association was observed between α2A-1291C > G polymorphism and D-IBS. Thus, α2 AR gene may be a potential candidate involved in the pathophysiology of D-IBS.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinica Chimica Acta - Volume 411, Issues 1–2, 4 January 2010, Pages 59–63
نویسندگان
, , , , , , ,