کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1966576 | 1538725 | 2009 | 5 صفحه PDF | دانلود رایگان |
BackgroundBiglycan (BGN), an extracellular matrix proteoglycan, has been shown to convey pro-inflammatory signals. In the present study we investigated BGN expression and its correlation with plasma levels of inflammatory markers in hypertensive subjects with or without alteration of carotid intima media thickness (IMT).MethodsWe evaluated 123 untreated essential hypertensives with no additional risk factors for atherosclerosis nor signs of cardiovascular disease and 40 controls. Hypertensives were classified according to a normal (≤ 1 mm) or increased (> 1 mm) IMT. BGN-mRNA and protein expression were measured in unstimulated, LPS- and Angiotensin II (Ang-II)-stimulated blood monocytes. Plasma concentrations of interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α) and high sensitivity-C-reactive protein (hs-CRP) were also measured.ResultsWe found increased levels of IL-6, TNF-α, hs-CRP, and BGN-mRNA and protein in hypertensives vs controls (1.72 ± 0.60 vs 1 n-fold, and 3.60 ± 0.75 vs 1 n-fold, both p < 0.001). However, BGN expression was not significantly different between hypertensives with IMT ≤ 1 mm and > 1 mm. Furthermore, in vitro addition of Ang II enhanced basal BGN-mRNA (in hypertensives: 3.57 ± 1.08 vs 1.72 ± 0.60 n-fold, p < 0.001) and protein (in hypertensives: 4.92 ± 0.42 vs 3.41 ± 0.75, p < 0.001) expression in monocytes.ConclusionsOur data provide evidence of an enhanced expression of BGN in essential hypertension. In addition we suggest that Ang II can mediate monocyte BGN production.
Journal: Clinica Chimica Acta - Volume 406, Issues 1–2, 11 August 2009, Pages 89–93