کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1966922 | 1538711 | 2010 | 8 صفحه PDF | دانلود رایگان |
BackgroundAcute (AMS) and chronic (CMS) mountain sicknesses are illnesses that occur among humans visiting or inhabiting high-altitude environments, respectively. Some individuals are genetically less fit than others when stressed by an extreme high-altitude environment. Seven blood physiological parameters and five genetic polymorphisms were studied in Han patients with AMS and Tibetan patients with CMS.MethodsWe compared 98 AMS patients with 60 Han controls as well as 50 CMS patients with 36 Tibetan controls. The genetic loci studied are ACE I/D (rs4340), AGT M235T (rs699), AGTR1 A1166C (rs5186), GNB3 A(− 350)G (rs2071057) and APOB A/G (rs693).ResultsAll physiological parameters (RBC, HCT, Hb, SaO2, HR, and BPs/d) studied significantly changed in the CMS patients while SaO2 and HR changed in the AMS Han patients compared to their controls. The ACE D and AGT 235 M alleles were found to be significantly associated with AMS and CMS, respectively, while a significantly high incidence of the G-protein (GNB3) (− 350)A allele was found in the AMS patients. ACE (I/D) was significantly associated with HR in CMS patients while the AGT M235T was significantly associated with SaO2 and BPs/d in AMS patients. APOB A/G was significantly associated with BPs/d in AMS and HR in CMS patients.ConclusionAMS and CMS share very similar genetic results for the ACE I/D and AGT M235T polymorphisms indicating that these mutations have an effect on both illnesses.
Journal: Clinica Chimica Acta - Volume 411, Issues 19–20, 9 October 2010, Pages 1466–1473