کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1967097 1538739 2008 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Association between the − 2518G/A polymorphism in the monocyte chemoattractant protein-1 (MCP-1) gene and myocardial infarction in Tunisian patients
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Association between the − 2518G/A polymorphism in the monocyte chemoattractant protein-1 (MCP-1) gene and myocardial infarction in Tunisian patients
چکیده انگلیسی

BackgroundMonocyte chemoattractant protein-1 (MCP-1; gene name CCL2) has been suggested to play an important role in the initiation of atherosclerosis by recruiting monocytes to sites of injured endothelium. Recently, single nucleotide polymorphisms (SNPs) in the MCP-1 regulatory region have been identified. Controversial results regarding the association of the − 2518G/A polymorphism of the MCP-1 gene with coronary artery disease (CAD) have been reported. In the present study, we examined a possible association between the − 2518G/A polymorphism of the MCP-1 gene and myocardial infarction (MI) in a sample of the Tunisian population.MethodsA total of 319 Tunisian patients with MI and 467 healthy controls were included in the study. The SNP of the MCP-1 gene was determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis.ResultsPatients with MI had significantly higher frequency of the AG + GG genotypes compared to controls [42.9% vs. 35.8%; OR (95%CI), 1.34 (1.00–1.79); p = 0.04]. The MI patient group showed a significant higher frequency of the G allele compared to the controls [0.242 vs. 0.195; OR (95%CI), 1.31(1.02–1.68), p = 0.03]. The association between the − 2518G/A polymorphism of the MCP-1 gene and MI was no longer significant after adjustment for other well-established risk factors.ConclusionThe present study showed a significant but not independent association between the − 2518G/A polymorphism of the MCP-1 gene (presence of G allele) and MI in the Tunisian population.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinica Chimica Acta - Volume 390, Issues 1–2, April 2008, Pages 122–125
نویسندگان
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