کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1967103 | 1538739 | 2008 | 4 صفحه PDF | دانلود رایگان |
BackgroundD-dimer testing is used to exclude thromboembolic disease in outpatients suspected of having deep venous thrombosis and pulmonary embolism.MethodsWe evaluated 4 D-dimer assays for imprecision and method comparison and evaluated the AxSYM® method for interference, linearity, and reference interval. Method comparison testing was performed using the following methods: Abbott AxSYM, bioMérieux mini VIDAS®, Diagnostica Stago STA Compact®, and Biosite Triage® Meter Plus.ResultsTotal CVs for all methods ranged from 3.7% for the STA Compact to 17.3% for the Triage Meter. The AxSYM showed good agreement with the other methods with slopes ranging from 1.17 to 1.22 by Passing–Bablok regression and correlation coefficients ≥ 0.96. Interference from hemolysis, icterus, and lipemia had < 7% deviation from the intended D-dimer concentration. Linearity had ≤ 11.5% deviation from target values.ConclusionsThe AxSYM D-dimer assay provides a precise, rapid, and user-friendly method for D-dimer testing with good correlation to other methods.
Journal: Clinica Chimica Acta - Volume 390, Issues 1–2, April 2008, Pages 148–151