کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1967559 1538746 2007 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Clinical validation of combined serological biomarkers for improved hepatocellular carcinoma diagnosis in 961 patients
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Clinical validation of combined serological biomarkers for improved hepatocellular carcinoma diagnosis in 961 patients
چکیده انگلیسی

BackgroundAlpha-fetoprotein (AFP), the only serological marker currently available for the detection of hepatocellular carcinoma (HCC), is unsatisfactory because of its poor sensitivity, as are other recently proposed markers. Therefore new biomarkers are badly needed. Squamous cell carcinoma antigen (SCCA), a serine protease inhibitor physiologically present in the skin, has recently been reported to be present in HCC patients, as also the immunocomplexed (IC) forms of SCCA and AFP: SCCAIC and AFPIC, respectively.MethodsTo determine the diagnostic accuracy of new serum biomarkers for the diagnosis of HCC a rapid, simple ELISA test was applied in 961 patients. Sensitivity and specificity were determined for each marker and for all the markers combined in detecting smaller and larger HCC versus liver cirrhosis.ResultsIn smaller HCC, receiver operating characteristics analysis yielded the following AUC: AFP 0.714 (CI 95% 0.679–0.748), AFPIC 0.691 (CI95% 0.655–0.748), SCCA 0.703 (CI95% 0.667–0.736), SCCAIC 0.694 (CI 95% 0.659–0.728). SCCA was inversely correlated with size. The combined use of AFPIC, SCCA and SCCAIC in patients displaying low levels of AFP (< 20 IU/mL) identified 25.6% HCC (186/725).ConclusionThis study suggests that the use of a combination of all these markers in clinical practice provides a non invasive and simple test that could increase the accuracy of HCC diagnosis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinica Chimica Acta - Volume 383, Issues 1–2, August 2007, Pages 147–152
نویسندگان
, , , , , , , , ,