کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1968179 1538761 2006 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Relationships between circulating matrix metalloproteinase-2 and -9 and renal function in patients with chronic kidney disease
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Relationships between circulating matrix metalloproteinase-2 and -9 and renal function in patients with chronic kidney disease
چکیده انگلیسی

BackgroundIt has been proven that extracellular matrix turnover is involved in the pathogenesis of various renal fibrosis diseases. Matrix metalloproteinase-2 and -9 (MMP-2 and -9) are the extracellular matrix degrading enzymes that are believed to play important roles in renal diseases. However, the relationship of circulating levels of MMP-2, -9 and serum creatinine in the patients of chronic kidney disease (CKD) has not yet been investigated.MethodsGelatin zymography and ELISA were employed to measure MMP-2 and MMP-9 activities in the plasma samples of 60 CKD patients and 40 control subjects.ResultsSerum creatinine concentrations and MMP-2 activities were significantly higher (p < 0.001) while MMP-9 activity and creatinine clearance (CCr) were significantly lower (p < 0.05 and p < 0.001, respectively) in CKD patients, as compared with those of control subjects. In addition, serum creatinine concentrations correlated with MMP-2 activity (R = 0.288, p < 0.05) and inversely correlated with that of MMP-9 (R = 0.344, p < 0.01).ConclusionsThis study demonstrated a correlation between MMP-2, -9 and serum creatinine in CKD patients to suggest that MMP-2 and MMP-9 might contribute in the pathogenesis of CKD.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinica Chimica Acta - Volume 366, Issues 1–2, April 2006, Pages 243–248
نویسندگان
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