کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1968298 | 1538764 | 2006 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Gold nanoparticle probes for the detection of nucleic acid targets Gold nanoparticle probes for the detection of nucleic acid targets](/preview/png/1968298.png)
BackgroundAdvances in nanoscience are having a significant impact on many scientific fields and are resulting in the development of a variety of important technologies. This impact is particularly large in the field of biodiagnostics, where a number of nanoparticle-based assays have been introduced for biomolecular detection, with DNA- or protein-functionalized gold nanoparticles used as the target-specific probes.MethodsAssays provide an analysis of the unique biophysical properties displayed by gold nanoparticles and have advantages over conventional detection methods (e.g., molecular fluorophores, real-time polymerase chain reaction, RT-PCR, enzyme linked immunosorbent assays, ELISAs, gel electrophoresis, and microarray technologies).ConclusionSome of the advantages include the assays' PCR-like sensitivity, their selectivity for target sequences, their capacity for massive multiplexing, their time efficiency, and most importantly, their ability to be performed at the point of care.
Journal: Clinica Chimica Acta - Volume 363, Issues 1–2, January 2006, Pages 120–126