کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1968941 | 1538882 | 2013 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Measuring the glomerular filtration rate in different age groups using iohexol, the protocol from the Belgian iohexol study Measuring the glomerular filtration rate in different age groups using iohexol, the protocol from the Belgian iohexol study](/preview/png/1968941.png)
ObjectivesMeasuring the exact glomerular filtration rate (GFR) is difficult. Iohexol can be used instead of inulin or labeled EDTA or DTPA. In recent years, different studies have validated GFR-estimating equations in adults. Validation of these estimations in adolescents and elderly is lacking. With this study, we aim to develop a simplified (only 1–3 blood collections) iohexol protocol to measure the true GFR for patients of all ages and try to develop GFR-estimating equations for adolescents and the elderly.Design and settingParticipants of different ages will be recruited: 50 adolescent (14–18 years) and 30 adults (20–65 years), 60 elderly (65–80 years) and 60 very elderly (80 + years old) stratified based on their GFR. Biometric data, serum creatinine and cystatin C will be measured. After injecting 5 mL iohexol, 9 blood samples will be taken between 20 and 360 min. First, the GFR will be calculated by using the double exponential decay method and different GFRs based on 1–3 blood samples, which will be compared with the GFR of the abovementioned 9 samples. Second, the GFR will be calculated by using new and existing equations and compared to the true GFR.DiscussionThe availability of a reliable GFR measurement is important in situations such as screening patients for kidney donation or when taking potentially nephrotoxic treatments. This study will allow us to develop a simplified protocol for measuring the true GFR in all ages and will allow us to validate existing equations and develop new eGFR equations for adolescents and the elderly.
► Measuring the exact GFR is complex.
► New GFR estimating equations are not always validated in all age groups.
► Iohexol is an exogenous substance which can be used to measure the GFR exactly.
► A simplified protocol for all ages to measure the GFR will be developed.
► Existing and new GFR estimating equation will be validated in different age groups.
Journal: Clinical Biochemistry - Volume 46, Issues 1–2, January 2013, Pages 31–36