Relaxin-3 is associated with metabolic syndrome and its component traits in women

ObjectivesRelaxin-3 was found to play a role in appetite regulation, increasing food intake and body weight. The current study aimed to investigate the relation of relaxin-3 to metabolic syndrome and its component traits in women.Design and methodsThe study was conducted on 300 female subjects, 150 healthy control and 150 metabolic syndrome patients. The component traits of metabolic syndrome were determined for all participants.ResultsSerum relaxin-3 level was significantly higher in the metabolic syndrome patients than in the healthy control group. It was also significantly correlated with all the component traits of metabolic syndrome.ConclusionThe results suggest that metabolic syndrome is associated with increased serum relaxin-3 levels in women. Relaxin-3 might be considered as a potential biomarker of metabolic syndrome.

Figure optionsDownload as PowerPoint slideHighlights
► We investigated the relation of relaxin-3 to metabolic syndrome in women.
► A case–control study was conducted on 150 healthy subjects and 150 patients.
► Serum relaxin-3 level was significantly higher in the metabolic syndrome patients.