کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1969550 1059775 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
PPARG gene promoter polymorphism is associated with non-traumatic hip fracture risk in the elderly Slovenian population: A pilot study
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
PPARG gene promoter polymorphism is associated with non-traumatic hip fracture risk in the elderly Slovenian population: A pilot study
چکیده انگلیسی

ObjectivesPeroxisome proliferator-activated receptor γ (PPARγ), an essential transcription factor for adipogenesis, has been implicated in pathogenesis of osteoporosis. The association of three single nucleotide polymorphisms in the PPARG gene with hip fracture risk, bone mineral density (BMD) and biochemical markers of bone turnover was investigated in the elderly.Design and methodsSix hundred sixty-seven elderly Slovenians were genotyped for SNPs rs12497191, rs1801282 and rs3856806. BMD and biochemical markers of bone turnover were measured. Haplotypes ACC, AGT and GCC, defined by rs12497191, rs1801282 and rs3856806 were assigned. Influence of genotype on fracture risk was assessed in 72 non-traumatic hip fracture cases and 272 controls.ResultsThe rs12497191 G allele alone or in haplotype was associated with lower risk of non-traumatic hip fracture and higher serum receptor activator of nuclear factor κB ligand.ConclusionsThe rs12497191 genotype could contribute to the incidence of non-traumatic hip fractures in the elderly.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Biochemistry - Volume 44, Issue 13, September 2011, Pages 1085–1089
نویسندگان
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