کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1970339 | 1059802 | 2012 | 4 صفحه PDF | دانلود رایگان |

ObjectivesTo investigate retinol-binding protein 4 (RBP4), small dense low-density lipoprotein cholesterol (sdLDL-C) and oxidized low-density lipoprotein (ox-LDL) levels and their associations in dyslipidemia subjects.Design and methodsWe determined RBP4, sdLDL-C, ox-LDL levels in 150 various dyslipidemia subjects and 50 controls. The correlation analysis and multiple linear regression analysis were performed.ResultsThe RBP4, sdLDL-C and ox-LDL levels were found increased in various dyslipidemia subjects. The sdLDL-C levels were positively correlated with RBP4 (r = 0.273, P = 0.001) and ox-LDL (r = 0.273, P = 0.001). RBP4 levels were also correlated with ox-LDL (r = 0.167, P = 0.043). The multiple regression analysis showed that only sdLDL-C was a significant independent predictor for RBP4 (β coefficient = 0.219, P = 0.009; adjusted R2 = 0.041) and ox-LDL (β coefficient = 0.253, P = 0.003; adjusted R2 = 0.057) levels, respectively.ConclusionsThe independent associations of sdLDL-C with RBP4 and ox-LDL were observed in dyslipidemia subjects. RBP4 may play an important role in lipid metabolism of atherosclerosis, particularly in formation of sdLDL.
► The RBP4, sdLDL-C and ox-LDL levels were increased in dyslipidemia subjects.
► A positive correlation was found among RBP4, sdLDL-C and ox-LDL levels.
► Only sdLDL-C was a significant independent predictor for both RBP4 and ox-LDL.
► RBP4 was involved in the formation of sdLDL, associated with atherosclerosis.
Journal: Clinical Biochemistry - Volume 45, Issue 9, June 2012, Pages 619–622