Time-dependent changes of myeloperoxidase in relation to in-hospital mortality in patients with the first anterior ST-segment elevation myocardial infarction treated by primary percutaneous coronary intervention

ObjectivesTo analyze the prognostic value of myeloperoxidase (MPO) in relation to in-hospital mortality and to identify the optimum time point for sampling in patients with the first anterior ST-segment elevation myocardial infarction (STEMI) treated by primary percutaneous coronary intervention (pPCI).Design and methodsA total of 100 consecutive patients with the first anterior STEMI undergoing pPCI were included. Blood samples were collected at baseline, 4, 8, 12, 18, 24, 48 and 168 hours (h) after pPCI.ResultsMPO concentrations have showed a biphasic pattern over time; the highest MPO levels were at4 h and 24 h after pPCI. In-hospital mortality was 6%. MPO at 24 h significantly correlated with troponin I as well as heart failure. After multivariate adjustment, MPO at 24 h was an independent predictor of the in-hospital mortality (OR 3.34, 95% CI 1.13–9.86, P = 0.029).ConclusionsIn patients with the first anterior STEMI treated by pPCI, MPO at 24 h after procedure was an independent predictor of the in-hospital mortality.

► Consecutive patients with the first anterior STEMI undergoing pPCI.
► MPO concentrations have shown a biphasic pattern over time.
► MPO measured 24 h after pPCI is an independent predictor of in-hospital mortality.