کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1970547 1059808 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Minimally modified electronegative LDL and its autoantibodies in acute and chronic coronary syndromes
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Minimally modified electronegative LDL and its autoantibodies in acute and chronic coronary syndromes
چکیده انگلیسی

Objectives:To determine the minimally modified electronegative LDL (LDL−) and its autoantibodies in coronary syndromes.Design and methods:LDL(−) and its autoantibodies were determined by ELISA in patients with acute (ACS, unstable angina; AMI, acute myocardial infarction) and chronic coronary syndromes (stable angina, SA) and compared to subjects without coronary disease (controls). Results are expressed as median of LDL− (μg/mL) and anti-LDL(−) IgG (OD405 nm).Results:The concentrations of LDL(−) were higher in patients with coronary disease (ACS: 40.7 μg/mL; SA: 35.0 μg/mL) as compared to controls (21.6 μg/mL). The highest LDL− concentrations were found in patients with AMI (41.8 μg/mL). Anti-LDL(−) IgG was elevated in ACS (1.143) in relation to CCS (0.527) and controls (0.467). A positive correlation was observed between anti-LDL− IgG and CRP levels (r  =  0.34, p  <  0.01) in the studied groups.Conclusions:LDL(−) and anti-LDL(−) autoantibodies may be useful markers to follow patients with high risk for coronary events.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Biochemistry - Volume 39, Issue 7, July 2006, Pages 708–714
نویسندگان
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