کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1970573 | 1538899 | 2010 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Proatherogenic disturbances in lipoprotein profile, associated enzymes and transfer proteins in women with iron deficiency anaemia Proatherogenic disturbances in lipoprotein profile, associated enzymes and transfer proteins in women with iron deficiency anaemia](/preview/png/1970573.png)
ObjectiveTo characterize the lipid-related atherogenic risk factors in iron deficiency anaemia (IDA) patients.Design and methodsTwenty IDA women were compared to healthy age-matched controls. Lipoprotein profile, cholesteryl ester transfer protein (CETP), paraoxonase (PON) 1 and lipoprotein-associated phospholipase A2 (LpPLA2) activities and plasma levels of oxidized-LDL were evaluated.ResultsTriglycerides were higher (median [range]) (1.0 [0.5–1.9] vs. 0.7 [0.5–1.5] mmol/L, p < 0.05) and HDL-C lower (mean ± SD) (1.3 ± 0.3 vs. 1.6 ± 0.4 mmol/L, p < 0.01) in the patients group. CETP (197 ± 29% vs. 151 ± 29% mL− 1 h− 1, p < 0.001), PON 1 (122 ± 17 vs. 140 ± 33 μmol mL− 1 min− 1, p < 0.05) and LpPLA2 (9.6 ± 2.0 vs. 8.1 ± 1.7 μmol mL− 1 h− 1, p < 0.05) activities were different in IDA women. No difference was observed in oxidized-LDL. Haemoglobin correlated negatively with triglycerides (r = − 0.35, p < 0.05), CETP (r = − 0.62, p < 0.001) and LpPLA2 (r = − 0.34, p < 0.05), while ferritin was positively associated with HDL-C (r = 0.39, p < 0.05) and inversely with CETP (r = − 0.49, p < 0.005).ConclusionThe alterations in lipoprotein profile, CETP, PON 1 and LpPLA2 activities described in the present study indicate that non-treated IDA might represent a proatherogenic state.
Journal: Clinical Biochemistry - Volume 43, Issues 4–5, March 2010, Pages 416–423