کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1970718 | 1059816 | 2006 | 6 صفحه PDF | دانلود رایگان |
ObjectivesBone turnover is regulated locally by osteoprotegerin (OPG) and receptor activator of NFκB ligand (RANK-L); it is not known how the circulating concentrations of these cytokines reflect renal osteodystrophy.MethodsWe measured serum OPG, RANK-L, parathyroid hormone (iPTH), collagen C-terminal cross-linked telopeptide (βCrossLaps), and bone densitometry (BMD) in 79 patients with end-stage renal disease (ESRF) undergoing dialysis. A hand X-ray of these patients was also analyzed. Controls were 65 healthy subjects.ResultsESRF patients had high OPG and RANK-L levels; RANK-L was higher in hemodialysis than in peritoneal dialysis. OPG and RANK-L did not depend on iPTH. The bone markers were significantly increased and correlated with serum iPTH, but not with OPG or RANK-L; neither OPG nor RANK-L correlated significantly with BMD. OPG was significantly higher in patients with acro-osteolysis.ConclusionsOPG and RANK-L serum concentrations do not strongly reflect bone status in ESRF. However, OPG was significantly higher in patients with acro-osteolysis.
Journal: Clinical Biochemistry - Volume 39, Issue 6, June 2006, Pages 617–622