کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1971103 1059837 2010 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The impact of acute atrial fibrillation on the prothrombotic state in patients with essential hypertension
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
The impact of acute atrial fibrillation on the prothrombotic state in patients with essential hypertension
چکیده انگلیسی

ObjectivesTo investigate whether acute atrial fibrillation (AF) creates a prothrombotic state in hypertensive patients, and to assess the evolution in research indices after cardioversion.Design and methodsPlasma levels of von Willebrand factor (vWf), soluble P-selectin and fibrin D-dimers were measured in hypertensive patients with acute AF pre-cardioversion and at 1, 7, 14, and 30 days post-cardioversion. The results were compared with hypertensive controls and healthy controls.ResultsPre-cardioversion plasma vWf levels in acute AF patients were similar to those of controls; however, post-cardioversion, the vWf levels increased significantly and only returned to baseline levels 14 days later. Compared with controls, acute AF patients had higher levels of fibrin D-dimers, which lasted at least 14 days after cardioversion.ConclusionsThis study demonstrated that hypertensive patients with acute AF have an abnormal prothrombotic state, which persists for up to 14 days after cardioversion.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Biochemistry - Volume 43, Issue 15, October 2010, Pages 1212–1215
نویسندگان
, , , , , , , ,