کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1971166 1538896 2010 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
TNF-α −308G > A and IL-6 −174G > C polymorphisms in Tunisian patients with coronary artery disease
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
TNF-α −308G > A and IL-6 −174G > C polymorphisms in Tunisian patients with coronary artery disease
چکیده انگلیسی

ObjectiveOur aim was to evaluate the contribution of tumor necrosis factor (TNF)-α −308G > A and interleukin (IL)-6 −174G > C gene promoter variants to the presence of coronary artery disease (CAD) in Tunisians.Design and methodsStudy subjects comprised 418 angiographically proven CAD patients and 406 age-, gender-, and ethnic origin-matched controls. Genotyping was performed using polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analysis.ResultsThere were no significant differences in the allelic distribution of TNF-α −308A (19.6% vs. 19.0%, P = 0.73), and IL-6 −174C (15.6% vs. 14.3%, P = 0.47) promoter polymorphisms between CAD patients and control subjects, respectively. In addition, single locus analysis revealed no differences in genotype frequencies between the two study groups, and the combined distribution of both genotypes did not differ significantly between controls and CAD patients (P > 0.05).ConclusionThere is no allelic or genotypic association of TNF-α −308G > A and IL-6 −174G > C promoter polymorphisms with CAD in Tunisians, thereby confirming an ethnic-selective contribution of both gene variants to CAD presence.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Biochemistry - Volume 43, Issues 13–14, September 2010, Pages 1085–1089
نویسندگان
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