کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1971315 1059849 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Brain natriuretic peptide correlates with the extent of atrial fibrillation-associated silent brain lesions
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Brain natriuretic peptide correlates with the extent of atrial fibrillation-associated silent brain lesions
چکیده انگلیسی

ObjectiveIdentification of plasma markers indicative for atrial fibrillation-associated silent brain lesions.Design and methods1. Comparative determination of the plasma concentrations of secretagogin, S100B, neuropeptide Y, brain fatty acid binding protein, matrix metalloprotease 9, brain natriuretic peptide, and of D-Dimer in 222 patients with atrial fibrillation and 28 controls by immunoassays. 2. Correlation of the biochemical marker plasma concentration with the extent of silent white matter brain lesions, as determined by the Fazekas score and N-acetylaspartate-spectroscopy.Results1. Plasma concentrations of brain natriuretic peptide, of neuropeptide Y, and of matrix metalloprotease 9 were significantly higher (all with a p < 0.05) in patients suffering from atrial fibrillation than in control subjects. 2. Brain natriuretic peptide correlated significantly with the Fazekas score (R = 0.41; p < 0.005). 3. Brain natriuretic peptide plasma concentrations were significantly higher in patients with a pathological N-acetylaspartate magnetic resonance-spectrometry (p < 0.05).ConclusionBrain natriuretic peptide plasma concentrations correlate with the extent of atrial fibrillation-associated silent brain lesions.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Biochemistry - Volume 41, Issue 18, December 2008, Pages 1434–1439
نویسندگان
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