Correlation of oxidative status with BMI and lung function in COPD

Objectives:The imbalance in oxidative status together with nutrition depletion and low body weight play a vital role in the pathogenesis and severity of chronic obstructive pulmonary disease (COPD). The study was undertaken to ascertain if a relationship existed between oxidative status and BMI in COPD. In addition, association of oxidative status and BMI with lung function of the disease was also examined.Materials and methods:In 202 COPD patients and 136 healthy controls plasma lipid peroxidation (LPO), reduced glutathione (GSH), glutathione peroxidase (GPx), catalase (CAT) activities, BMI and FEV1% predicted were looked for interactions.Results:The patients had increased LPO (p = 0.006) and decreased antioxidants (GSH, p = 0.005; GPx, p = 0.035 and CAT, p = 0.008, respectively). Of note are the correlations of oxidative stress markers with BMI and FEV1% predicted in the patients. LPO inversely and GSH, GPx, and CAT positively correlated with both BMI (p = 0.007, p < 0.001, p = 0.045 and p = 0.009, respectively), and FEV1% of predicted (LPO, p = 0.001; GSH, p < 0.001; GPx, p = 0.043 and CAT, p < 0.001) in the patients. Further, a positive correlation existed between BMI and FEV1% predicted (p = 0.016) in COPD.Conclusion:The intimate relationship of oxidative status with BMI and lung function, and the direct correlation between BMI and FEV1 may potentiate severity of the disease.