کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1971625 | 1538910 | 2008 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: The concept of precision extended to the atherogenic index of plasma The concept of precision extended to the atherogenic index of plasma](/preview/png/1971625.png)
BackgroundThe atherogenic index of plasma (AIP), defined as the base 10 logarithm of the ratio of plasma triglyceride (TG) to high density lipoprotein cholesterol (HDL-C), has been employed as a predictor of cardiovascular risk. We seek to quantify the analytical precision of the AIP using the coefficients of variation (CVs) of the TG and HDL-C assays.MethodsError propagation methods are employed to develop a simple formula for the standard deviation of the random analytical error in the AIP assuming that the errors in the TG and HDL-C assays are normally distributed. An alternative derivation assuming log-normal distribution of errors gives nearly identical results while avoiding subtle technical problems.ResultsThe SD of the AIP is given by σAIP≅1ln(10)CVTG2+CVHDL-C2 and this formula will provide SD results that are accurate within 0.4% for CVs of TG and HDL-C less than 5%, as compared with results of Monte Carlo simulation. We also explain that the concept of CV cannot be applied to the AIP since it is a logarithm.ConclusionsThe formula provides a simple means to quantify the precision of the AIP from precision data available for the TG or HDL-C assays.
Journal: Clinical Biochemistry - Volume 41, Issues 7–8, May 2008, Pages 631–635