کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1975963 | 1060667 | 2008 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: The role of thyroid hormones during the development of eye pigmentation in the Pacific bluefin tuna (Thunnus orientalis) The role of thyroid hormones during the development of eye pigmentation in the Pacific bluefin tuna (Thunnus orientalis)](/preview/png/1975963.png)
Thyroid hormones (THs) are essential for the embryonic and post-embryonic development of fish. We studied the role of THs during the early, post-embryonic, development of Pacific bluefin tuna. Embryos were treated with L-thyroxine (T4) or the anti-thyroid drug methimazole (MMI), and reared in microtitre plates for 3 days. Immersion in MMI, but not T4, led to retardation of retinal pigment epithelium (RPE) pigmentation 3 days post-hatching (dph). Concurrent immersion in T4 and MMI had no effect of RPE pigmentation. We also measured the expression of TRαA, TRαB, and TRβ mRNA using real-time RT-PCR. Treatment with MMI significantly reduced TRβ mRNA expression. Taken together these results suggest that the development of RPE pigmentation is mediated by TH, most likely via TRβ.
Journal: Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology - Volume 150, Issue 1, May 2008, Pages 112–116