کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1977188 | 1539281 | 2015 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Use of zebrafish as a model to investigate the role of epigenetics in propagating the secondary complications observed in diabetes mellitus
ترجمه فارسی عنوان
استفاده از ماهی قزل آلا به عنوان یک مدل برای بررسی نقش اپی ژنتیک در انتشار عوارض جانبی ثانویه دیابت
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
TETcytosine–phosphate–guanineMCM2Dnmt1GLUTPARPSTZCpGROS - ROSstreptozotocin - استرپتوزوتوسینEpigenetics - اپی ژنتیکDiabetes - بیماری قندmetabolic memory - حافظه متابولیکGlucose transporter - حمل و نقل گلوکزDiabetes mellitus - دیابت قندیAge - سنTranscription factor - عامل رونویسیVascular endothelial growth factor - فاکتور رشد اندوتلیال عروقیVascular Endothelial Growth Factor (VEGF) - فاکتور رشد اندوتلیال عروقی (VEGF)Hyperglycemia - هایپرگلایسمیpoly-ADP ribose polymerase - پلی-ADP ریبوز پلی مرازadvanced glycation end product - پیشرفته محصول نهایی گلیساسیونZebrafish - گورخرماهیReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
چکیده انگلیسی
Diabetes mellitus (DM) is classified as a disease of metabolic dysregulation predicted to affect over 400 million individuals world-wide by 2030. The debilitating aspects of this disease are the long term complications involving microvascular and macrovascular pathologies. These long term complications are related to the clinical phenomenon of metabolic memory (MM) that is defined as the persistence of diabetic complications even after glycemic control has been pharmacologically achieved. The persistent nature of MM has invoked involvement of epigenetic processes. Current research with the DM/MM zebrafish model as described in this review as well as human and mammalian studies has established that changes in DNA methylation patterns appear to contribute to tissue dysfunctions associated with DM. This review will describe studies on an adult zebrafish model of type I diabetes mellitus that allows analysis of both the hyperglycemic (HG or DM) phase and MM phase of the disease. The review will discuss the model in regards to: 1) its hyperglycemic phase, 2) its MM phase, 3) biochemical õpathways underlying changes in DNA methylation patterns observed in the model, 4) loci specific changes in DNA methylation patterns, and 5) strengths of the adult zebrafish model as compared to other MM animal models.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology - Volume 178, December 2015, Pages 3-7
Journal: Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology - Volume 178, December 2015, Pages 3-7
نویسندگان
Michael P. Jr., Alexey A. Leontovich, Robert V. Intine,