کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1977664 | 1061507 | 2009 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Exogenous folate ameliorates ethanol-induced brain hyperhomocysteinemia and exogenous ethanol reduces taurine levels in chick embryos
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کلمات کلیدی
HEPESTHFEtOHdithiotreitolDTTSAMS-adenosylhomocysteineSAH10-Formyltetrahydrofolate dehydrogenase - 10-فرمول تترا هیدرو فولات دهیدروژنازEthanol - اتانولEDTA - اتیلن دی آمین تترا استیک اسید ethylenediamine-tetraacetic acid - اتیلندیامین-تتراستیک اسیدS-adenosylmethionine - اس-ادنوزیل متیونینTaurine - تائورینtetrahydrofolate - تتراهیدروفولاتChick - جوجه Folate - فولاتhomocysteine - هوموسیستئین
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The effects of exogenous ethanol and/or folic acid on endogenous homocysteine (HoCys) and SAM (S-adenosylmethionine)/SAH (S-adenosylhomocysteine) levels in chick brains were studied at 11 days of development. Embryonic EtOH (3.0 mmol/kg egg) exposure caused a 1.6-fold increase in brain HoCys levels and a 9-fold decrease in brain SAM/SAH levels as compared to controls (p â¤Â 0.05). Brain HoCys and SAM/SAH levels returned to control values when injected with a mixture of EtOH and folic acid (3.0 mmol EtOH/kg egg and 34 μmol folic acid/kg egg). The effects of exogenous EtOH on the remethylation pathway, as measured by 10-formyltetrahydrofolate dehydrogenase (10-FTHF DH) activities, and the transsulfuration pathway, as measured by taurine levels, were studied at 18 days of development. A single dosage of EtOH (3.0 mmol/kg egg; E0) and two daily dosages of EtOH (E0-1) failed to influence brain and hepatic 10-FTHF DH activities when compared to controls. However, three daily dosages of EtOH (E0-2) caused approximately a two-fold increase in brain 10-FTHF DH activities and a three-fold increase in hepatic 10-FTHF DH activities as compared to controls (p â¤Â 0.05). Three daily EtOH dosages (E0-2) caused reduced taurine levels in both brain and hepatic tissues (p â¤Â 0.05). Meanwhile, a single EtOH dosage (E0), two daily EtOH dosages (E0-1), and three daily EtOH dosages (E0-2), caused reduced hepatic taurine levels as compared to controls (p â¤Â 0.05).
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology - Volume 150, Issue 1, July 2009, Pages 107-112
Journal: Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology - Volume 150, Issue 1, July 2009, Pages 107-112
نویسندگان
Robert K. Barnett, Stephanie L. Booms, Tracy Gura, Mara Gushrowski, Robert R. Jr.,