Keywords: تتراهیدروفولات; Flavoenzymes; Folate; Mutagenesis; Enzyme kinetics; Reductase; Glutamine; CH2-H4folate; 5,10-methylenetetrahydrofolate; CH3-H4folate; 5-methyltetrahydrofolate; DHFR; dihydrofolate reductase; E. coli; Escherichia coli; EDTA; ethylenediaminetetraacetic acid
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Keywords: تتراهیدروفولات; One carbon metabolism; Cancer metabolism; Serine hydroxymethyltransferase; Isozymes; Enzyme inhibition; Pyrazolopyran scaffold; Pyridoxal 5â²-phosphate; PLP; serine hydroxymethyltransferase; SHMT; cytosolic SHMT; SHMT1; mitochondrial SHMT; SHMT2; Escheri
Keywords: تتراهیدروفولات; Folic acid; Folate; Fortification; Supplementation; Neural tube defect; Primary prevention; ASD; autism spectum disorder; BfR; Bundesinstitut für Risikobewertung, Federal Republic of Germany; Cbl; cyanocobalamin; CDC; Centers for Disease Control and Prev
Keywords: تتراهیدروفولات; MTR; 5-methyl tetrahydrofolate-homocysteine methyl transferase; MTHFD; methylene tetrahydrofolate dehydrogenase; MTHFC; methylene tetrahydrofolate cyclohydrolase; FTHFS; formyl tetrahydrofolate synthase; THF; tetrahydrofolate; CBS; cystathionine-beta-synt
Keywords: تتراهیدروفولات; One-carbon metabolism; Folate; Choline; Epigenetics; DNA methylation; Histone modifications; THF; tetrahydrofolate; MAT; methionine adenosyltransferase; GNMT; glycine N-methyltransferase; SAdoHcy; S-adenosylhomocysteine; SAHH; S-adenosylhomocysteine hydro
Keywords: تتراهیدروفولات; CH2THF; 5,10-methylene tetrahydrofolate; DCD; dCTP deaminase; DCD-DUT; bifunctional dCTP deaminase-dUTPase; DUT; dUTPase; DHF; dihydrofolate; DHFR; dihydrofolate reductase; DHFR-TS; bifunctional dihydrofolate reductase - thymidylate synthase; FAD; f
Keywords: تتراهیدروفولات; 2Nal; 3-(2-naphthy)-alanine; AFWK; pheylalanine/tryptophan/lysine triple auxotrophic E. coli; DHB; 2,5-dihydroxybenzoic acid; DHF; dihydrofolate; DHFR; dihydrofolate reductase; Glu; glutamic acid; LB; Lria-Broth; Lys; lysine; MALDI-TOF MS; matrix-assisted
Keywords: تتراهیدروفولات; Cultivars; Folates; Pulses; Liquid chromatography; Mass spectrometry; Quantification; Food analysis; Food composition; FA; folic acid; 10-FFA; 10-formylfolic acid; 5-FTHF; 5-formyltetrahydrofolate; 5,10-MTHF; 5,10-methenyltetrahydrofolate; 5-MTHF; 5-methy
Keywords: تتراهیدروفولات; AdoMet; S-adenosylmethionine; DHF; dihydrofolate; DHFR; DHF reductase; ENU; ethylnitrosourea; ESTR; Expanded Simple Tandem Repeat; FA; folic acid; MTHFR; 5,10-methylenetetrahydrofolate reductase; MN; micronucleus; CD24-; Pig-a mutant phenotype; NCE; normo
Keywords: تتراهیدروفولات; ADH1; alcohol dehydrogenase 1; BMP; bone morphogenic protein; CRL; Charles River Laboratories; EtOH; ethanol; ADH3; formaldehyde dehydrogenase; FA; formic acid; GD; gestational day; H2O2; hydrogen peroxide; ip; intraperitoneal; MeOH; methanol; NZW; New Ze
Keywords: تتراهیدروفولات; ACSS; acetyl-CoA synthetase; ADI; arginine deiminase; AML; acute myeloid leukaemia; AMPK; AMP-activated protein kinase; ALL; acute lymphoblastic leukaemia; ASS; argininosuccinate synthase; BCAAs; branched-chain amino acids; BPTES; bis-2-(5-phenylacetamido
Keywords: تتراهیدروفولات; Folate fortification; Bread; Swiss chard; Spinach; H4-folate; tetrahydrofolate; 5-CH3-H4-folate; 5-methyl tetrahydrofolate;
Keywords: تتراهیدروفولات; Folate intake; Requirements; Pregnancy; DFEs; dietary folate equivalents; DHFR; dihydrofolate reductase; DRI; Dietary Reference Intake; EAR; Estimated Average Requirements; FA; folic acid; MCV; mean corpuscular volume (MCV); MTHFR; methylenetetrahydrofola
Keywords: تتراهیدروفولات; FDH; 10-formyltetrahydrofolate dehydrogenase; THF; tetrahydrofolate; dpf; day-post-fertilization; hpf; hour-post-fertilization; MO; morpholino oligonucleotide; WISH; whole-mount in situ hybridization; FDH-N-ter; FDH N-terminal domain; Zebrafish; ROS; Cell
Keywords: تتراهیدروفولات; ÎrGâ²; Transformed Gibbs energy of a reaction; ÎrGâ²m; Transformed Gibbs energy of a reaction under reactant concentrations of 1Â mM; THF; Tetrahydrofolate; Electrosynthesis; Formatotrophic growth; Biomass yield; Thermodynamic favorability; Chemical m
New in vitro model derived from brain-specific Mut-/- mice confirms cerebral ammonium accumulation in methylmalonic aciduria
Keywords: تتراهیدروفولات; 2-MCA; 2-methylcitrate; AKG; α-ketoglutarate; BBB; blood-brain barrier; CSF; cerebrospinal fluid; CNS; central nervous system; cTIN; chronic tubulointerstitial nephritis; DIV; day in vitro; FGF; fibroblast growth factor; GalC; galactocerebroside; GDH; gl
Kinetics and thermodynamics of the thermal inactivation and chaperone assisted folding of zebrafish dihydrofolate reductase
Keywords: تتراهیدروفولات; Zebrafish dihydrofolate reductase; Thermal inactivation of zDHFR; Kinetics and thermodynamics of thermal denaturation; GroEL-ES and minichaperone assisted folding of zDHFR; Fluorescence and CD spectroscopy of zDHFR; zDHFR; Zebrafish Dihydrofolate reductas
Computational elucidation of novel antagonists and binding insights by structural and functional analyses of serine hydroxymethyltransferase and interaction with inhibitors
Keywords: تتراهیدروفولات; SHMT; Serine hydroxymethyltransferase; Ld; Leishmania donovani; PLP; Pyridoxal phosphate; THF; Tetrahydrofolate; TS; Thymidylate synthase; PDB; Protein Data Bank; NCBI; National Center for Biotechnology Information; DOPE; Discrete optimized protein energy
Folate stability and method optimization for folate extraction from seeds of pulse crops using LC-SRM MS
Keywords: تتراهیدروفولات; ESI-SRM MS; electrospray ionization-selective reaction monitoring mass spectrometry; 5-CH3-5,6-H2PteGlu; 5-methyl-5,6-dihydrofolate; 5-CHO-H4PteGlu; 5-formyltetrahydrofolate; 5-CH3-H4PteGlu; 5-methyltetrahydrofolate; 5,10-CHH4PteGlu5; 10-methenyltetrahydr
Insights into the role of methionine synthase in the universal 13C depletion in O- and N-methyl groups of natural products
Keywords: تتراهیدروفولات; l-methionine; l-methionine synthase (EC 2.1.1.14); O-methyl and N-methyl groups; 13C/12C isotope fractionation; 13C NMR; QM/MM theoretical calculation; AdoMet; S-adenosylmethionine; EA; elemental analyzer; EIE; equilibrium isotope effect; Hcy; homocystein
Folates in quinoa (Chenopodium quinoa), amaranth (Amaranthus sp.) and buckwheat (Fagopyrum esculentum): Influence of cooking and malting
Keywords: تتراهیدروفولات; Dietary reference value; Total folates; Retention factor; 5-methyltetrahydrofolate; 10-formyltetrahydrofolate; Folic acid; Tetrahydrofolate; 5 formyltetrahydrofolate; Pseudocereals;
Computational analysis for the determination of deleterious nsSNPs in human MTHFD1 gene
Keywords: تتراهیدروفولات; In silico analysis; Human MTHFD1 gene polymorphism; Single nucleotide polymorphisms; Folate metabolism; MTHFD15; 10-methylenetetrahydrofolate dehydrogenase 1; SIFT; sorting intolerant from tolerant; SNPs&GO; single nucleotide polymorphisms and gene ontolo
Human and Plasmodium serine hydroxymethyltransferases differ in rate-limiting steps and pH-dependent substrate inhibition behavior
Keywords: تتراهیدروفولات; Serine hydroxymethyltransferase; Pyridoxal 5â²-phosphate; Tetrahydrofolate; Ligand binding; Rapid-quench flow; Substrate inhibition; Rate determining step;
Molecular architecture of an N-formyltransferase from Salmonella enterica O60
Keywords: تتراهیدروفولات; CHES; 2-(cyclohexylaminoethanesulfonic acid); dTDP; thymidine diphosphate; Fuc3N; 3-amino-3,6-dideoxygalactose; Fuc3NFo; 3-formamido-3,6-dideoxygalactose; HEPPS; N-2-hydroxyethylpiperazine-Nâ²-3-propanesulfonic acid; HPLC; high-performance liquid chromat
Microbial catabolism of chemical herbicides: Microbial resources, metabolic pathways and catabolic genes
Keywords: تتراهیدروفولات; 2,4-D; 2,4-dichlorophenoxyacetic acid; MCPA; 2-methyl-4-chlorophenoxyacetic acid; DCSA; 3,6-dichlorosalicylic acid; DCGA; 3,6-dichlorogentisate; DCMP; 3,6-dichloromaleylpyruvate; THF; tetrahydrofolate; ALS; acetolactate synthase; AHAS; acetohydroxyacid sy
The unexpected extremophile: Tolerance to fluctuating salinity in the green alga Picochlorum
Keywords: تتراهیدروفولات; HGT; horizontal gene transfer; DE; differentially expressed; ASW; artificial seawater; FRRF; fast repetition rate fluorometer; STF; single turnover flash; PSII; photosystem II; WOC; water-oxidizing complex; QF; quality factor; FDR; false discovery rate; L
MTHFD1 regulates nuclear de novo thymidylate biosynthesis and genome stability
Keywords: تتراهیدروفولات; MTHFD1; SHMT; TYMS; DHFR; Thymidylate; Folate; Lamin; DNA replication; Multi-enzyme complex; FOCM; folate-mediated one-carbon metabolism; MTHFD1; methylenetetrahydrofolate dehydrogenase 1; SHMT1; cytoplasmic serine hydroxymethyltransferase; TYMS; thymidyl
ReviewFlavin-Dependent Methylation of RNAs: Complex Chemistry for a Simple Modification
Keywords: تتراهیدروفولات; SAM; S-adenosyl-L-methionine; m5U; 5-methyluridine; tmRNA; transfer-mRNA; CH2Â =Â THF; N5,N10-methylenetetrahydrofolate; FAD; flavin adenine dinucleotide; ThyA; thymidylate synthase; dUMP; desoxyuridine monophosphate; THF; tetrahydrofolate; ThyX; thymidyl
Genetic animal models to decipher the pathogenic effects of vitamin B12 and folate deficiency
Keywords: تتراهیدروفولات; Vitamin B12; Folate; Methyl donor deficiency; Pathogenesis; Genetic animal models; B12; vitamin B12; SAM; S-adenosylmethionine; SAH; S-adenosylhomocysteine; HCY; homocysteine; KO; knock-out; ES cells; embryonic stem cells; OCM; one-carbon metabolism; NTD;
Glutathione metabolism links FOXRED1 to NADH:ubiquinone oxidoreductase (complex I) deficiency: A hypothesis
Keywords: تتراهیدروفولات; ABC; ATP-binding cassette; ADH3; alcohol dehydrogenase 3; ALDH; aldehyde dehydrogenase; CFTR; cystic fibrosis transmembrane conductance regulator; CPS1; carbamoyl phosphate synthase; DMGDH; dimethylglycine dehydrogenase; DHF; dihydrofolate; DMGO; dimethyl
Metabolic flux analysis of the halophilic archaeon Haladaptatus paucihalophilus
Keywords: تتراهیدروفولات; 13C-assisted metabolism analysis; Glycine biosynthesis; Halophilic archaea; Isoleucine biosynthesis; Lysine biosynthesis; SHMT; Serine hydroxymethyltransferase; TA; threonine aldolase; GCS; glycine cleavage system; TCA; tricarboxylic acid; THF; tetrahydro
MYC and metabolism on the path to cancer
Keywords: تتراهیدروفولات; 2-DG; 2-deoxyglucose; 4E-BP; eIF4E-binding protein; 5,10-methylene THF; 5,10-methylenetetrahydrofolate; ACC; acetyl-CoA carboxylase; ACLY; ATP-citrate lyase; AMPK; AMP-activated protein kinase; ATP; adenosine triphosphate; ChIP-seq; chromatin immunoprecip
Ligand binding studies, preliminary structure-activity relationship and detailed mechanistic characterization of 1-phenyl-6,6-dimethyl-1,3,5-triazine-2,4-diamine derivatives as inhibitors of Escherichia coli dihydrofolate reductase
Keywords: تتراهیدروفولات; Mechanistic characterization; Inhibition kinetics; Escherichia coli dihydrofolate reductase; QSAR; Drug discovery; 2,4-Diamino-1,3,5-triazine; 2,4-Diamino 1,2,4-triazine; EcDHFR; Escherichia coli dihydrofolate reductase; NADPH; nicotinamide adenine dinucl
Hyperhomocysteinemia: Related genetic diseases and congenital defects, abnormal DNA methylation and newborn screening issues
Keywords: تتراهیدروفولات; AHCY; adenosylhomocysteinase; BHMT; betaine-homocysteine methyl-transferase; Cbl-C; cobalamin C; CHD; congenital heart defects; CTH; cystathionine-γ-lyase; CBS; cystathionine-β-synthase; DS; Down syndrome; hHcy; hyperhomocysteinemia; Hcy; homocysteine
Metabolic flux analysis of recombinant Pichia pastoris growing on different glycerol/methanol mixtures by iterative fitting of NMR-derived 13C-labelling data from proteinogenic amino acids
Keywords: تتراهیدروفولات; αKG; α-ketoglutarate; GA3P; Glyceraldehyde-3-phosphate; PG2; 2-phosphoglycerate; PG3; 3-phosphoglycerate; GA3Pper; Glyceraldehyde-3-phosphate peroxisome; DHA; Dihydroxyacetone; DHAP; Dihydroxyacetone phosphate; E4P; Eritrose-4-phosphate; Rib5P; Ribose-5
Coenzyme-inspired chemistry 1: the C-2 alkylation of 4,5-dihydroimidazoles
Keywords: تتراهیدروفولات; Dihydroimidazole; Alkylation; C1-transfer; Tetrahydrofolate; Coenzyme mimic;
Analysis of subcellular [57Co] cobalamin distribution in SH-SY5Y neurons and brain tissue
Keywords: تتراهیدروفولات; AdoCbl; adenosyl cobalamin; Cbl; cobalamin; Hcy; homocysteine; LAMP2; lysosomal-associated membrane protein 2; LER; Lysosome Enrichment Reagent; Met; methionine; MS; methionine synthase; MeCbl; methyl Cbl; MMCM; methylmalonyl-coenzyme A mutase; 5-methyl-T
Mitochondrial DNA methylation as a next-generation biomarker and diagnostic tool
Keywords: تتراهیدروفولات; AD; Alzheimer disease; AIMs; amplification of inter-methylated sites; ALS; amyotrophic lateral sclerosis; ChIP; chromatin immunoprecipitation; CTH; cystathionine γ-lyase; CHARM; comprehensive high-throughput arrays for relative methylation; CBS; cystathi
Folate polyglutamylation eliminates dependence of activity on enzyme concentration in mitochondrial serine hydroxymethyltransferases from Arabidopsis thaliana
Keywords: تتراهیدروفولات; One-carbon metabolism; Folate polyglutamylation; Serine hydroxymethyltransferase (SHMT); Tetrahydrofolate;
Exploration of structure-function relationships in Escherichia coli cystathionine γ-synthase and cystathionine β-lyase via chimeric constructs and site-specific substitutions
Keywords: تتراهیدروفولات; OAS; O-acetylserine; AVG; aminoethoxyvinylglycine; CBL; cystathionine β-lyase; CGL; cystathionine γ-lyase; CGS; cystathionine γ-synthase; Cth; cystathionine; Hcys; homocysteine; HO-HxoDH; d-2-Hydroxyisocaproate dehydrogenase; IPTG; Isopropyl-β-d-thiog
Solvent environments significantly affect the enzymatic function of Escherichia coli dihydrofolate reductase: Comparison of wild-type protein and active-site mutant D27E
Keywords: تتراهیدروفولات; CD; circular dichroism; CSM; center of fluorescence spectral mass; DHF; dihydrofolate; DHFR; dihydrofolate reductase; HSQC; heteronuclear single quantum correlation; MES; 2-(N-morpholino)ethanesulfonic acid; MTE; 50Â mM MES, 25Â mM Tris 25Â mM ethanolamin
Effect of germination and subsequent oven-drying on folate content in different wheat and rye cultivars
Keywords: تتراهیدروفولات; Wheat; Rye; Germination; Folate; H4folate; tetrahydrofolate; 5-HCO-H4folate; 5-formyl-tetrahydrofolate; 5-CH3-H4folate; 5-methyl-tetrahydrofolate; 10-HCO-PteGlu; 10-formyl folic acid; PteGlu; pteroyl-l-glutamic acid; DM; dry matter; FD; freeze-dri
Pressure dependence of activity and stability of dihydrofolate reductases of the deep-sea bacterium Moritella profunda and Escherichia coli
Keywords: تتراهیدروفولات; CD; circular dichroism; DHF; dihydrofolate; DHFR; dihydrofolate reductase; ecDHFR; Escherichia coli DHFR; mpDHFR; Moritella profunda DHFR; THF; tetrahydrofolate; Cavity; Hydration; Deep sea; Dihydrofolate reductase; Molecular adaptation; Moritella profund
Liquid chromatography/time-of-flight mass spectrometry for the analysis of plant samples: A method for simultaneous screening of common cofactors or nucleotides and application to an engineered plant line
Keywords: تتراهیدروفولات; LC-MS; NAD; Arabidopsis; Nicotinate; Nucleotides; AdoHCys; S-adenosyl homocysteine; ADPG; ADP-glucose; Glut; glutathion; Me-THF; methyl-tetrahydrofolate; NaMN; nicotinate-d-ribonucleotide; NaAD; deamino-NAD+; NMR; nuclear magnetic resonance; RuBP; ribul
Exogenous folate ameliorates ethanol-induced brain hyperhomocysteinemia and exogenous ethanol reduces taurine levels in chick embryos
Keywords: تتراهیدروفولات; DTT; Dithiotreitol; EtOH; Ethanol; EDTA; Ethylenediamine-tetraacetic acid; 10-FTHF DH; Formyltetrahydrofolate dehydrogenase; HEPES; N-[2-hydroxyethyl]piperazine-Nâ² [2-ethanesulfonic acid]; HoCys; Homocysteine; SAH; S-adenosylhomocysteine; SAM; S-adenosy
Catalytic and ligand-binding characteristics of Plasmodium falciparum serine hydroxymethyltransferase
Keywords: تتراهیدروفولات; DHFR; dihydrofolate reductase; TS; thymidylate synthase; mTHF; 5,10-methylenetetrahydrofolate; THF; tetrahydrofolate; dUMP; 2â²-deoxyuridine monophosphate; Malaria; Inhibitor; Enzyme; Kinetics; RNA binding;
Methylenetetrahydrofolate reductase (MTHFR) C677T and thymidylate synthase promoter (TSER) polymorphisms in Indonesian children with and without leukemia
Keywords: تتراهیدروفولات; ALL; acute lymphoblastic leukemia; CH2-THF; 5,10-methylenetetrahydrofolate; DDH; double distilled water; DHF; dihydrofolate; DHFR; dihydrofolate reductase; dTMP; deoxythymidine monophosphate; dTTP; deoxythymidine triphosphate; dUMP; deoxyuridine monophosp
Computer modelling of antifolate inhibition of folate metabolism using hybrid functional petri nets
Keywords: تتراهیدروفولات; Folate metabolism; Purine; Pyrimidine; Enzyme inhibition; Antifolates; HFPN; hybrid functional petri nets; GON; genomic object net; DHF; dihydrofolate; THF; tetrahydrofolate; 5-CHO-THF; 5-formyl-THF; 5; 10-CH2-THF; 5; 10-methylene-THF; MTX; methotrexate;
Effects of Intramuscular Injections of Vitamin B12 on Lactation Performance of Dairy Cows Fed Dietary Supplements of Folic Acid and Rumen-Protected Methionine*
Keywords: تتراهیدروفولات; lactation; vitamin B12; folic acid; rumen-protected methionine; ECM; energy-corrected milk; 5-methyl-THF; 5-methyl-tetrahydrofolate; SAM; S-adenosylmethionine; THF; tetrahydrofolate;
Enzymatic characterization of human mitochondrial C1-tetrahydrofolate synthase
Keywords: تتراهیدروفولات; C1-THF synthase; Tetrahydrofolate; Formate; One-carbon metabolism;