کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1979156 1061664 2011 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Challenges for the prediction of macromolecular interactions
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Challenges for the prediction of macromolecular interactions
چکیده انگلیسی

Macromolecular interactions are central to most cellular processes. Experimental methods generate diverse data on these interactions ranging from high throughput protein–protein interactions (PPIs) to the crystallised structures of complexes. Despite this, only a fraction of interactions have been identified and therefore predictive methods are essential to fill in the numerous gaps. Many predictive methods use information from related proteins. Accordingly, we review the conservation of interface and ligand binding sites within protein families and their association with conserved residues and Specificity Determining Positions. We then review recent developments in predictive methods for the identification of PPIs, protein interface sites and small molecule ligand binding sites. The challenges that are still faced by the community in these areas are discussed.


► Conservation of interfaces and ligand binding site across structural space.
► Advances in methods for protein–protein interaction (PPI) prediction.
► Advances in methods for PPI interface prediction.
► Methods for the prediction of small molecule ligand binding sites.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Structural Biology - Volume 21, Issue 3, June 2011, Pages 382–390
نویسندگان
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