کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1979170 1061665 2011 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The chaperone–histone partnership: for the greater good of histone traffic and chromatin plasticity
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
The chaperone–histone partnership: for the greater good of histone traffic and chromatin plasticity
چکیده انگلیسی

Histones are highly positively charged proteins that wrap our genome. Their surface properties also make them prone to nonspecific interactions and aggregation. A class of proteins known as histone chaperones is dedicated to safeguard histones by aiding their proper incorporation into nucleosomes. Histone chaperones facilitate ordered nucleosome assembly and disassembly reactions through the formation of semi-stable histone–chaperone intermediates without requiring ATP, but merely providing a complementary protein surface for histones to dynamically interact with. Recurrent ‘chaperoning’ mechanisms involve the masking of the histone's positive charge and the direct blocking of crucial histone surface sites, including those required for H3–H4 tetramerization or the binding of nucleosomal DNA. This shielding prevents histones from engaging in premature or unwanted interactions with nucleic acids and other cellular components. In this review, we analyze recent structural studies on chaperone–histone interactions and discuss the implications of this vital partnership for nucleosome assembly and disassembly pathways.


► Basic histone proteins are crucial for DNA packing but are prone to aggregation.
► Specialized histone chaperones tightly escort free histones throughout their life.
► Recent structure–function studies start to elucidate the chaperoning mechanism.
► Chaperones mask histone–histone and histone–DNA interaction sites.
► Chaperones facilitate productive nucleosome (dis)assembly and favour chromatin plasticity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Structural Biology - Volume 21, Issue 6, December 2011, Pages 698–708
نویسندگان
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