کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1979334 | 1061675 | 2011 | 6 صفحه PDF | دانلود رایگان |
Structural genomics approaches on integral membrane proteins have been postulated for over a decade, yet specific efforts are lagging years behind their soluble counterparts. Indeed, high throughput methodologies for production and characterization of prokaryotic integral membrane proteins are only now emerging, while large-scale efforts for eukaryotic ones are still in their infancy. Presented here is a review of recent literature on actively ongoing structural genomics of membrane protein initiatives, with a focus on those aimed at implementing interesting techniques aimed at increasing our rate of success for this class of macromolecules.
► Structural genomics techniques have been developed for membrane proteins.
► Structures of prokaryotic and eukaryotic membrane proteins can be determined.
► High throughput methods increase chances of finding a ‘well-behaved’ membrane protein.
Journal: Current Opinion in Structural Biology - Volume 21, Issue 4, August 2011, Pages 517–522