Hybrid approaches: applying computational methods in cryo-electron microscopy

Recent advances in cryo-electron microscopy have led to an increasing number of high (3–5 Å) to medium (5–10 Å) resolution cryoEM density maps. These density maps contain valuable information about the protein structure but frequently require computational algorithms to aid their structural interpretation. It is these hybrid approaches between cryoEM and computational protein structure prediction algorithms that will shape protein structure elucidation from density maps.