کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1979640 | 1061692 | 2007 | 12 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: The AAA+ superfamily — a myriad of motions The AAA+ superfamily — a myriad of motions](/preview/png/1979640.png)
ATPases associated with various cellular activities are aptly named. They are the engines that drive processes such as protein degradation, protein refolding, σ54-dependent transcriptional activation, DNA helicase activity, DNA replication initiation, and cellular cargo transport. Recent structural information derived from biochemical studies, electron microscopy (EM), small-angle X-ray scattering (SAXS), and X-ray crystallography are beginning to show how, at an atomic level, some of these systems use the conformational changes generated during the ATP hydrolysis cycle. Structural highlights in the processes mentioned are provided by work on ClpX and p97, ClpB, PspF and NtrC, RuvBL1, DnaA and the papillomavirus E1 initiator protein and dynein. The results emphasize the versatility of the AAA+ core domain.
Journal: Current Opinion in Structural Biology - Volume 17, Issue 6, December 2007, Pages 641–652