کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1979649 | 1061692 | 2007 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
MAD contortions: conformational dimerization boosts spindle checkpoint signaling
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
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چکیده انگلیسی
Almost two decades after their identification, the components of the mitotic checkpoint are finally revealing their structural secrets. The activation of Mad2, a central piece of the checkpoint protein machinery, is linked to the rare ability of this protein to adopt two distinct topologies. Current models of checkpoint function propose that the topological transition between the two states of Mad2 is rate limiting for checkpoint activation and is accelerated through a self-activation process based on the direct interaction of the two Mad2 conformers. These models add a molecular framework to an old theory that depicts kinetochores as catalysts in the generation of the mitotic checkpoint signal.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Structural Biology - Volume 17, Issue 6, December 2007, Pages 716–725
Journal: Current Opinion in Structural Biology - Volume 17, Issue 6, December 2007, Pages 716–725
نویسندگان
Marina Mapelli, Andrea Musacchio,