کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1979651 | 1061692 | 2007 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Versatility of polyketide synthases in generating metabolic diversity Versatility of polyketide synthases in generating metabolic diversity](/preview/png/1979651.png)
Polyketide synthases (PKSs) form a large family of multifunctional proteins involved in the biosynthesis of diverse classes of natural products. Architecturally at least three different types of PKSs have been discovered in the microbial world and recent years have revealed tremendous versatility of PKSs, both in terms of their structural and functional organization and in their ability to produce compounds other than typical secondary metabolites. Mycobacterium tuberculosis exploits polyketide biosynthetic enzymes to synthesize complex lipids, many of which are essential for its survival. The functional significance of the large repertoire of PKSs in Dictyostelium discoideum, perhaps in producing developmental regulating factors, is emerging. Recently determined structures of fatty acid synthases (FASs) and PKSs now provide an opportunity to delineate the mechanistic and structural basis of polyketide biosynthetic machinery.
Journal: Current Opinion in Structural Biology - Volume 17, Issue 6, December 2007, Pages 736–743