کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1980074 1539396 2015 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The Repeat Expansion Diseases: The dark side of DNA repair
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
The Repeat Expansion Diseases: The dark side of DNA repair
چکیده انگلیسی

DNA repair normally protects the genome against mutations that threaten genome integrity and thus cell viability. However, growing evidence suggests that in the case of the Repeat Expansion Diseases, disorders that result from an increase in the size of a disease-specific microsatellite, the disease-causing mutation is actually the result of aberrant DNA repair. A variety of proteins from different DNA repair pathways have thus far been implicated in this process. This review will summarize recent findings from patients and from mouse models of these diseases that shed light on how these pathways may interact to cause repeat expansion.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: DNA Repair - Volume 32, August 2015, Pages 96–105
نویسندگان
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