Human MutS and FANCM complexes function as redundant DNA damage sensors in the Fanconi Anemia pathway

► MutS complexes are required for the activation of the Fanconi Anemia pathway. ► MSH2 but not MLH1 depleted cells are sensitive to DNA crosslinking agents. ► MSH2 is required for the chromatin recruitment of the FA core complex upon DNA damage. ► MutS and FANCM complexes function as redundant DNA damage sensors in the Fanconi Anemia pathway.