کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1980697 1061875 2008 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Smc5–Smc6 complex suppresses gross chromosomal rearrangements mediated by break-induced replications
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Smc5–Smc6 complex suppresses gross chromosomal rearrangements mediated by break-induced replications
چکیده انگلیسی

Translocations in chromosomes alter genetic information. Although the frequent translocations observed in many tumors suggest the altered genetic information by translocation could promote tumorigenesis, the mechanisms for how translocations are suppressed and produced are poorly understood. The smc6–9 mutation increased the translocation class gross chromosomal rearrangement (GCR). Translocations produced in the smc6–9 strain are unique because they are non-reciprocal and dependent on break-induced replication (BIR) and independent of non-homologous end joining. The high incidence of translocations near repetitive sequences such as δ sequences, ARS, tRNA genes, and telomeres in the smc6–9 strain indicates that Smc5–Smc6 suppresses translocations by reducing DNA damage at repetitive sequences. Synergistic enhancements of translocations in strains defective in DNA damage checkpoints by the smc6–9 mutation without affecting de novo telomere addition class GCR suggest that Smc5–Smc6 defines a new pathway to suppress GCR formation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: DNA Repair - Volume 7, Issue 9, 1 September 2008, Pages 1426–1436
نویسندگان
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