کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1980996 1061892 2007 20 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Arrested replication fork processing: Interplay between checkpoints and recombination
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Arrested replication fork processing: Interplay between checkpoints and recombination
چکیده انگلیسی
The arrest of DNA replication by DNA damage, nucleotide depletion, DNA-protein complexes or following clashes between transcription and replication factors all have the capacity to promote genome instability. In this review, we discuss how DNA replication is regulated by the checkpoint pathways that stabilise arrested replication forks and the recombination factors that process specific DNA structures resulting from fork arrest. We examine what is known about the interplay between the checkpoints and the recombination apparatus and review the evidence for a recombination-based fork restart pathway in eukaryotes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: DNA Repair - Volume 6, Issue 7, 1 July 2007, Pages 1042-1061
نویسندگان
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