کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1981270 1061915 2009 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Population-specific variation in haplotype composition and heterozygosity at the POLB locus
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Population-specific variation in haplotype composition and heterozygosity at the POLB locus
چکیده انگلیسی

DNA polymerase beta plays a central role in base excision repair (BER), which removes large numbers of endogenous DNA lesions from each cell on a daily basis. Little is currently known about germline polymorphisms within the POLB locus, making it difficult to study the association of variants at this locus with human diseases such as cancer. Yet, approximately thirty percent of human tumor types show variants of DNA polymerase beta. We have assessed the global frequency distributions of coding and common non-coding SNPs in and flanking the POLB gene for a total of 14 sites typed in approximately 2400 individuals from anthropologically defined human populations worldwide. We have found a marked difference between haplotype frequencies in African populations and in non-African populations.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: DNA Repair - Volume 8, Issue 5, 1 May 2009, Pages 579–584
نویسندگان
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