The Wnt pathway destabilizes adherens junctions and promotes cell migration via β-catenin and its target gene cyclin D1

▸ We analyzed the effects of cyclin D1 on the migration of cancer cell lines. ▸ The Wnt pathway promotes cellular migration via its target gene cyclin D1. ▸ Cyclin D1 rearranges the actin cytoskeleton and destabilizes adherens junctions.