CD248 expression on mesenchymal stromal cells is required for post-natal and infection-dependent thymus remodelling and regeneration

▸ The mesenchymal stromal cell marker CD248 is expressed in the thymus on pericytes. ▸ Genetic deletion of CD248 prevents full post-natal development of the thymus. ▸ Genetic deletion of CD248 prevents infection-dependent regeneration following thymic atrophy. ▸ CD248 regulates blood endothelial vessel formation in the thymus.