Proteomics and transcriptome analysis coupled with pharmacological test reveals the diversity of anti-thrombosis proteins from the medicinal insect, Eupolyphaga sinensis

► One hundred and five fibrin(ogen)olytic proteins were identified from the ground beetle, Eupolyphaga sinensis. ► Thrombolytic agents containing both direct-acting fibrin(ogen)olytic and plasminogen-activating activities. ► The current fibrino(gen)olytic enzymes could hydrolyze α-, β-, and γ-chains of fibrinogen. ► These proteins appear to be excellent templates to study structure-function relationship of serine proteases. ► The present work identifies novel thrombolytic agents with prospecting clinical potential.