کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1983562 | 1539899 | 2013 | 11 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Flavonoids as prospective compounds for anti-cancer therapy Flavonoids as prospective compounds for anti-cancer therapy](/preview/png/1983562.png)
Flavonoids, which are polyphenolic compounds, are a class of plant secondary metabolites possessing a broad spectrum of pharmacological activity including anti-cancer activities. They have been reported to interfere in the initiation, promotion and progression of cancer by modulating different enzymes and receptors in signal transduction pathways related to cellular proliferation, differentiation, apoptosis, inflammation, angiogenesis, metastasis and reversal of multidrug resistance. Due to their multiple molecular mechanisms of action, flavonoids (both natural and synthetic analogs) are being investigated for their potential applications in anti-cancer therapies. In this review article, the main molecular mechanisms of action of flavonoids attributing to their potential anti-cancer activities have been discussed and the key structural features required for their activity are highlighted.
Journal: The International Journal of Biochemistry & Cell Biology - Volume 45, Issue 12, December 2013, Pages 2821–2831