کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1984188 1539947 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
NKG2D and its ligands
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
NKG2D and its ligands
چکیده انگلیسی

NKG2D is an activating immunoreceptor, first recognized on NK cells but subsequently found on γδ T cells, CD8+ αβ T cells and macrophages. In NK cells, inhibitory signals are generally dominate over activating signals. However, activating signals mediated through engagement of NKG2D by its ligands on target cells can bypass signals transmitted through inhibitory NK receptors, allowing NKG2D to function as a “master-switch” in determining the activation status of NK cells. NKG2D is important for T cell and NK cell-mediated immunity to viruses and tumours, and has roles in autoimmune disease, allogeneic transplantation, and xenotransplantation. Depending upon the situation, development of strategies to either block or to enhance the interactions between NKG2D and its ligands may have important implications for human health and disease.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The International Journal of Biochemistry & Cell Biology - Volume 41, Issue 12, December 2009, Pages 2364–2367
نویسندگان
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