کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1984298 1539936 2010 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Peroxin 5: A cycling receptor for protein translocation into peroxisomes
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Peroxin 5: A cycling receptor for protein translocation into peroxisomes
چکیده انگلیسی

Peroxins are proteins that regulate the biogenesis of peroxisomes—small vesicular subcellular organelles essential for human life and health. A key peroxin – to date the best studied – is peroxin 5. Structurally, peroxin 5 is a bi-domain protein of about 70 kDa containing both globular and non-globular segments and displaying conformational flexibility. Functionally, it is a cycling receptor for importing essential enzymes into the peroxisome lumen, facilitated by highly promiscuous interactions with numerous proteins and possibly lipids. Peroxin 5 has medical significance in that (i) congenital defects can lead to fatal peroxisome biogenesis disorders, (ii) inefficient peroxisome targeting is linked to disease and aging and (iii) differences between human peroxin 5 and homologues in pathogens may be exploited in the development of therapeutics.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The International Journal of Biochemistry & Cell Biology - Volume 42, Issue 11, November 2010, Pages 1771–1774
نویسندگان
, ,