کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1984477 | 1539942 | 2010 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: The TAK1–TRAF6 signalling pathway The TAK1–TRAF6 signalling pathway](/preview/png/1984477.png)
Cellular responses to pathogens, growth factors, cytokines, extra- or intra-cellular stress, is a prerequisite for the cell to adapt to novel and potentially dangerous situations. If the changes in the extra- or intra-cellular milieu causes DNA-damage or revoke a signalling pathway utilized during morphogenesis, the epithelial cells might be forced to undergo programmed cell death (apoptosis) in the benefit for the whole organism or transform to a mesenchymal cell type (epithelial to mesenchymal transition; EMT), in respond to a specific stimuli. An overview is presented over the current knowledge for the key components in signal transduction in homeostasis, inflammation and cancer. A handful of transcription factors are crucial for the determination of the specific cellular responses, where the transforming growth factor-β (TGF-β) is an important factor as discussed in this review.
Journal: The International Journal of Biochemistry & Cell Biology - Volume 42, Issue 5, May 2010, Pages 585–589