کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1984537 | 1539941 | 2010 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Cross-talk between transforming growth factor-β and Wingless/Int pathways in lung development and disease Cross-talk between transforming growth factor-β and Wingless/Int pathways in lung development and disease](/preview/png/1984537.png)
Lung development depends on accurate and precise patterning of a pulmonary anlagen, consisting of both endodermally and mesodermally derived progenitor cells. In this process, the need to establish communication and control among individual cells is paramount. Transforming growth factor-β (TGFβ) and Wingless/int (Wnt) signaling pathways serve this need. The individual functional repertoire of the two pathways is further expanded by cross-talk and integration of signaling at multiple levels taking advantage of their hard-wired multi-component signal transduction platforms. Cross-talk creates the possibility for both specificity and versatility in signaling during development and during repair of injured tissue. Understanding the mechanics and the physiological implications of this cross-talk is necessary for therapeutic or preventive targeting of either TGFβ or Wnt signaling pathways.
Journal: The International Journal of Biochemistry & Cell Biology - Volume 42, Issue 6, June 2010, Pages 809–812