کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1984643 1539960 2008 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Know thy Sef: A novel class of feedback antagonists of receptor tyrosine kinase signaling
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Know thy Sef: A novel class of feedback antagonists of receptor tyrosine kinase signaling
چکیده انگلیسی

The strength and duration of intracellular signals must be precisely regulated, since inappropriate signaling can cause disease. Negative feedback mechanisms provide an effective means of controlling growth factor-mediated signaling, either by restricting the incoming signal or by inducing counter-regulatory mechanisms affecting signal propagation. Sef proteins represent a new class of feedback antagonists capable of regulating receptor tyrosine kinase signaling. The involvement of Sef in development, as well as in other biological processes, was demonstrated by biochemical and genetic approaches.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The International Journal of Biochemistry & Cell Biology - Volume 40, Issue 10, 2008, Pages 2040–2052
نویسندگان
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